[Verse 1]
Opioids first, let's autopsy the class
Mu-receptor agonists binding brainstem and spinal mass
Morphine, oxycodone, fentanyl patch
Inhibit adenylyl cyclase, potassium channels detach
Hyperpolarize the neuron, signal can't dispatch
Indications: acute and chronic pain, palliative attach
Contraindications — respiratory depression, watch your match
Paralytic ileus, head trauma, raised ICP
Monitor sedation scores or patients stop breathing free
Naloxone reversal sitting close, that antidote's the key
[Chorus]
Механизм, показания — знай их все
Indications, contraindications, adverse effects, dosе
Every analgesic class got a profile to compose
Запомни: onset, peak, duration — medicina flows
Mecanismo nel sangue, la farmacologia
Pain medicine, analgesic pharmacologia
[Verse 2]
NSAIDs next — COX inhibitors in the lab
COX-one protects the gut, COX-two fires the inflammatory jab
Nonselective agents hit both isoforms with a stab
Ibuprofen, naproxen — renally toxic, GI drab
Celecoxib spares the stomach but cardiovascular's the cab
Contraindicated: peptic ulcer, renal compromise, last trimester grab
Prostaglandin synthesis blocked, platelet aggregation slabs
Rare word incoming — analgesia's cousin: nociception
The actual transduction of damage into perception
Block the cyclooxygenase and intercept that signal's inception
[Chorus]
Механизм, показания — знай их все
Indications, contraindications, adverse effects, dosе
Every analgesic class got a profile to compose
Запомни: onset, peak, duration — medicina flows
Mecanismo nel sangue, la farmacologia
Pain medicine, analgesic pharmacologia
[Verse 3]
Local anesthetics — sodium channel blockade precise
Lidocaine, bupivacaine, ropivacaine, roll the dice
Smaller unmyelinated fibers blocked at lower price
Pain fibers first, then motor fibers sacrifice
Epinephrine co-injection vasoconstricts the splice
Prolongs the block, reduces systemic spice
Contraindicate epi on digits, ears, or penile device
Bupivacaine cardiotoxic — lipid emulsion is your vice
Toxicity presents as perioral tingling, then seizure, cardiac slice
Max dosing matters: lidocaine two to four milligrams per kilo precise
[Bridge]
Now adjuvants — the word is vellichor
That wistful ache of forgotten pharmacology lore
Gabapentinoids dampen calcium channel signal's core
TCAs modulate descending inhibition's floor
Ketamine NMDA antagonist, dissociative metaphor
Clonidine alpha-two, reduces central amplification's roar
Combine them wisely, multimodal is the score
Opioid-sparing strategy knocks at every door
[Chorus]
Механизм, показания — знай их все
Indications, contraindications, adverse effects, dosе
Every analgesic class got a profile to compose
Запомни: onset, peak, duration — medicina flows
Mecanismo nel sangue, la farmacologia
Pain medicine, analgesic pharmacologia