[Verse 1]
Tissue damage drops the signal, inflammatory cascade flows
Prostaglandins flood the area, bradykinin starts to grow
Nerve growth factor binds the nociceptor, threshold drops below
Peripheral sensitization — your pain receptors on overdrive, bro
Cytokines from macrophages amplify the transduction game
COX-2 cranking prostaglandins, nothing feels the same
Primary hyperalgesia at the wound site, allodynia creeping in
That's the periphery talking loud before the central stuff begins
[Chorus]
Wind-up, LTP, NMDA keys unlock the gate
Glial cells screaming, sodium channels replicate
Ectopic firing, disinhibition — GABAergic brakes are gone
Nociplastic pain got no lesion but the signal still carries on
Peripheral, central, neuropathic — three lanes of sensitization
Chronification is the destination when acute becomes foundation
[Verse 2]
Now the dorsal horn is listening different, synaptic gain increased
Glutamate hammers NMDA, magnesium block released
Calcium flooding into neurons, kinase activation spreads
Long-term potentiation etching new pathways in your threads
Microglia and astrocytes join the amplification choir
Pro-inflammatory cytokines — IL-1, TNF — throw fuel in the fire
Wind-up means each repeated stimulus hits progressively harder
Central sensitization rewrites the map, pain volume getting larger
[Chorus]
Wind-up, LTP, NMDA keys unlock the gate
Glial cells screaming, sodium channels replicate
Ectopic firing, disinhibition — GABAergic brakes are gone
Nociplastic pain got no lesion but the signal still carries on
Peripheral, central, neuropathic — three lanes of sensitization
Chronification is the destination when acute becomes foundation
[Verse 3]
Neuropathic lane — the axon's damaged but still generating sparks
Nav one-point-seven upregulated, misfiring in the dark
Sympathetic fibers sprouting baskets round the DRG
Norepinephrine activating pain fibers — that ain't how it's supposed to be
Disinhibition knocks the interneurons out, descending control fails
Serotonin-norepinephrine balance tips and inhibition derails
Now meet nociplastic — fibromyalgia, IBS, chronic low back
No structural lesion found on imaging but the suffering is fact
[Bridge]
Acute goes chronic when catastrophizing meets genetic soil
Post-surgical pain, psychological distress, the transition starts to boil
Opioid-induced hyperalgesia — dynorphin spikes, NMDA wakes again
The drug meant to dull the signal paradoxically amplifies pain
Risk factors stack like comorbidities — depression, anxiety, fear-avoidance trap
Understanding chronification means rewriting the analgesic map
[Chorus]
Wind-up, LTP, NMDA keys unlock the gate
Glial cells screaming, sodium channels replicate
Ectopic firing, disinhibition — GABAergic brakes are gone
Nociplastic pain got no lesion but the signal still carries on
Peripheral, central, neuropathic — three lanes of sensitization
Chronification is the destination when acute becomes foundation