[Verse 1]
Endocannabinoid system, let me break it clean
CB1 receptors poppin' in the brain machine
CB2 peripheral, immune cells on patrol
Anandamide and two-AG runnin' the whole scroll
Retrograde signaling, presynaptic suppression
Modulate the pain gate, that's the core lesson
Eleven cannabinoids we gotta dissect today
Phytocannabinoids, synthetic, endogenous relay
[Chorus]
THC, CBD, nabilone, nabiximols
Four keys to the kingdom when neuropathic pain calls
Spasticity, cancer pain, evidence we appraise
Schedule the receptor, count the adverse phase
Eleven cannabinoids — lock 'em in your brain
CB1, CB2, retrograde the lane
Agonist, antagonist, partial in the mix
Know your regulatory status or you'll catch no fix
[Verse 2]
THC is delta-nine, partial CB1 agonist
Psychoactive, antiemetic, analgesic specialist
CBD non-intoxicating, modulates the pain
TRPV1 and serotonin running through its vein
Nabilone synthetic, THC analog prescribed
Chemotherapy nausea, Schedule Two derived
Nabiximols is Sativex, oromucosal spray
THC plus CBD ratio, spasticity at bay
Multiple sclerosis patients getting functional relief
Neuropathic pain adjunct, measured on belief
[Chorus]
THC, CBD, nabilone, nabiximols
Four keys to the kingdom when neuropathic pain calls
Spasticity, cancer pain, evidence we appraise
Schedule the receptor, count the adverse phase
Eleven cannabinoids — lock 'em in your brain
CB1, CB2, retrograde the lane
Agonist, antagonist, partial in the mix
Know your regulatory status or you'll catch no fix
[Bridge]
Adverse effects catalogue, memorize the stack
Tachycardia, paranoia, cognitive hijack
Dizziness, dry mouth, psychosis in susceptible
Cannabinoid hyperemesis, cyclical inceptible
Drug interactions — CYP three-A-four and two-C-nine
Warfarin, clobazam, sedatives align
Additive CNS depression, flag it every time
Pregnancy contraindicated, pediatric climb
Evidence appraisal — moderate for neuropathic nerve
Cochrane says the numbers modest but the signal holds a curve
Number needed to treat around ten to twelve
Weigh the NNH against the benefit on the shelf
[Verse 3]
Regulatory status shifts state to federal ground
Schedule One federal but exemptions come around
Epidiolex is FDA approved CBD pure
Dravet syndrome, Lennox-Gastaut, seizure cure
Dronabinol Schedule Three, appetite in AIDS
Cancer cachexia, antiemetic cascades
Physician gotta document the indication clear
Titrate slow, start low, watch for adverse gear
Informed consent includes the psychiatric risk
Dependency potential seven to nine percent brisk
[Chorus]
THC, CBD, nabilone, nabiximols
Four keys to the kingdom when neuropathic pain calls
Spasticity, cancer pain, evidence we appraise
Schedule the receptor, count the adverse phase
Eleven cannabinoids — lock 'em in your brain
CB1, CB2, retrograde the lane
Agonist, antagonist, partial in the mix
Know your regulatory status or you'll catch no fix