[Verse 1] From neocortex down to entorhinal gate Layer two begins the trisynaptic fate Perforant path to dentate gyrus flows First synapse where the pattern encoding goes Mossy fibers carry sparse and clean DG to CA3, the sharpest scene Schaffer collaterals complete the chain CA3 to CA1, the memory train [Chorus] Three synapses dancing through the hippocampal core Direct paths bypass what came before Theta waves at four to twelve hertz strong Gamma nests inside to sing along Hold the circuit diagram tight in mind Trisynaptic loop with shortcuts intertwined [Verse 2] But wait there's more than classic pathways show Direct routes let the information flow Layer two can jump straight to CA3 Perforant path alternative you see Layer three takes temporoammonic flight Straight to CA1 without the fight Parallel processing, dual highway lanes Backup routes for memory's refrains [Chorus] Three synapses dancing through the hippocampal core Direct paths bypass what came before Theta waves at four to twelve hertz strong Gamma nests inside to sing along Hold the circuit diagram tight in mind Trisynaptic loop with shortcuts intertwined [Bridge] CA3 talks back to CA3 recursive Recurrent networks, memory immersive Commissural bridges span the hemisphere divide DG, CA3, CA1 on either side CA1 to subiculum the journey goes Deep layer EC where it all flows home [Verse 3] Theta rhythm rules the exploration game REM sleep and movement stake their claim Phase precession marks the temporal code Different phases choose encode or decode Gamma frequencies in nested embrace Thirty to one hundred, cell assembly space Slow gamma rides CA3's input stream Fast gamma surfs EC's routing scheme [Verse 4] When offline mode takes control at night Replay consolidates what felt just right Sharp wave ripples in the quiet hours Transfer memories using hippocampus powers From temporary store to cortical home The trisynaptic loop has found its zone Subiculum bridges to the final stage Neocortex completes the memory page [Verse 5] Place cells fire when location's found Grid cells map the spatial ground Time cells count the moments passing by Border cells mark boundaries that lie Pattern separation makes each memory unique While pattern completion helps recall technique Neurogenesis adds fresh granule cells Adult-born neurons with stories to tell [Chorus] Three synapses dancing through the hippocampal core Direct paths bypass what came before Theta waves at four to twelve hertz strong Gamma nests inside to sing along Hold the circuit diagram tight in mind Trisynaptic loop with shortcuts intertwined [Outro] EC layers two and three divide the flow DG, CA3, CA1 in sequence go Oscillations mark the rhythm's beat Memory circuit now complete
← Module 4 — CA1: comparator and output stage | Module 6 — Building the structure: patterning, neurogenesis, and migration →