[Verse 1] Call the registry ESPOIR, that's French for hope, Charting grafts in children learning how to cope, Three contenders on the runway, pick your road, Cryopreserved homograft hauling the heaviest load, Bovine jugular vein, a tough little tube, Decellularised homograft's the freedom-from-explant dude, Strip the cells, leave the scaffold bare like bone, Patient's own white cells repopulate the throne, Early numbers leaning toward the decell crew, Longer follow-up's pending — the story's not through. [Chorus] Decell, dissolve, donate, design, Four roads to a root that grows with time, Decell, dissolve, donate, design, Pick the valve that's living, not confined, Freedom from explant, freedom to grow, Chart it, track it, watch the registry flow. [Verse 2] Now picture a conduit built to disappear, Xeltis spins a supramolecular polymer here, Scaffold's just a trellis, a temporary frame, Fibroblasts come crawling in and claim the game, In situ tissue forms where the polymer used to be, Resorbs to nothing, leaves living history, Early trials running, the cohort still small, Dissolve and rebuild — let the body answer the call. [Chorus] Decell, dissolve, donate, design, Four roads to a root that grows with time, Decell, dissolve, donate, design, Pick the valve that's living, not confined, Freedom from explant, freedom to grow, Chart it, track it, watch the registry flow. [Verse 3] Twenty-twenty-two, Duke table, Turek holds the knife, First partial heart transplant gifting growing life, Not the whole organ, just the valve and the root, Living tissue stitched in, flexible as a shoot, It stretches with the child, no outgrowing the size, But the price is an immune war paid in compromise, Chimerism blooms — two genomes intertwined, Rare word, simple meaning: borrowed cells combined, Immunosuppression keeps the quiet peace within, Tacrolimus whispers so rejection can't begin. [Bridge] No single conduit wins for every heart, Size and age and anatomy all play their part, Judge it by the gradient, judge it by the years, A growing valve's the dream that quiets the fears, From homograft to printer, the goal's one thread, A conduit that ages like the child instead. [Verse 4] Seed a scaffold with the patient's own cell line, Grow it in a bioreactor, let it incubate in time, 3D printer lays the conduit layer by layer, Shaped by CFD math, a fluid-dynamics prayer, Simulate the flow before the knife ever cuts, Minimize the energy loss, no turbulent guts, Patient-specific geometry, tailored, never guessed, Still experimental — bench before the chest. [Chorus] Decell, dissolve, donate, design, Four roads to a root that grows with time, Decell, dissolve, donate, design, Pick the valve that's living, not confined, Freedom from explant, freedom to grow, Chart it, track it, watch the registry flow.
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