[Verse 1]
The cell forgets to wait for permission,
Sustained proliferative signal's the ignition,
Growth suppressors tossed out like old mail,
p53 and Rb just quietly fail,
Resisting death, the apoptosis switch gets cut,
Cancer's stubborn gut won't close the shutter up.
[Chorus]
Десять ознак — ten hallmarks in the chart,
Рак не спить, so learn the signs, play your part,
Growth and immortality, blood vessels drawn,
Invasion, metabolism, till the mask is gone,
Immune evasion hiding, признаки of the fight,
Хірург, вивчи карту — know them left to right.
[Verse 2]
Telomerase wakes up, rewinds the clock,
Chromosome tips rebuilt, an endless stock,
No Hayflick limit, no closing door,
Infinite divisions, the cell wants more,
VEGF whispers, vessels start to bloom,
Angiogenesis fills an empty room,
Bevacizumab blocks that whispered call,
But cut the signal near a surgical wall —
Wounds won't knit right, the healing's delayed,
Know your drugs before you lift the blade.
[Chorus]
Десять ознак — ten hallmarks in the chart,
Рак не спить, so learn the signs, play your part,
Growth and immortality, blood vessels drawn,
Invasion, metabolism, till the mask is gone,
Immune evasion hiding, признаки of the fight,
Хірург, вивчи карту — know them left to right.
[Verse 3]
Basement membrane breaks, the border gives,
Invasion and metastasis — where the danger lives,
Warburg effect, glucose burned up cheap,
Glycolysis chosen, even with oxygen to keep,
Lactate rising, mitochondria ignored,
Energy rewritten — the tumor's reward,
T-cells get fooled, checkpoints wave them through,
Evading immune destruction, hidden out of view.
[Verse 4]
Senescent cells linger, refusing to sleep,
Secreting chaos, promises they keep,
p16 stands guard, mounted in the gate,
Yet stress signals pile and tip the fate,
Клітини втомились, still they interfere,
Target the pathway — make the margin clear,
Resistance mutates, the therapy grows thin,
Watch the biomarkers before you begin.
[Bridge]
Underneath it all, two engines turn the wheel,
Genome instability — mistakes that feel too real,
Tumor-promoting inflammation stokes the flame,
Enabling traits, не ознаки, but they fan the game,
Every scalpel, every drug aims at a named hallmark,
Хірург повинен знати — don't operate in the dark.
[Chorus]
Десять ознак — ten hallmarks in the chart,
Рак не спить, so learn the signs, play your part,
Growth and immortality, blood vessels drawn,
Invasion, metabolism, till the mask is gone,
Immune evasion hiding, признаки of the fight,
Хірург, вивчи карту — know them left to right.
[Outro]
Знай ознаки, тримай у голові,
Ten hallmarks whispering what the tumor knows,
From Hanahan to Weinberg, the map still grows,
Знай ознаки — cut where the danger flows.