[Verse 1] Every tumor wears a badge, a molecular disguise, Trastuzumab reads the tag marked HER-two in disguise, Breast cells, stomach cells, both flashing the same sign, One antibody, one lock, one perfectly cut key design. [Chorus] HER-two, trastuzumab, that's the breast and gastric aim, KIT and PDGFRA, imatinib's the name, Osimertinib quiets EGFR's restless flame, BRAF plus MEK together — learn the targets, learn the game. [Verse 2] Down in the gut, a stromal cell forgets to ever rest, KIT or PDGFRA mutated, driving growth unchecked, Imatinib slips in the pocket, shuts the engine cold, Shrinks the GIST before the surgeon's story's even told, And lungs that carry EGFR mutations in their code Answer to osimertinib, even crossing the brain's own road. [Chorus] HER-two, trastuzumab, that's the breast and gastric aim, KIT and PDGFRA, imatinib's the name, Osimertinib quiets EGFR's restless flame, BRAF plus MEK together — learn the targets, learn the game. [Verse 3] Melanoma loves a mutation, BRAF at six-hundred-V, Block it, then block MEK too, so resistance can't break free, But the body's immune army carries its own built-in brakes, PD-one and CTLA-four, the checkpoints cancer fakes, Pembrolizumab and nivolumab lift the PD-one veil, Ipilimumab springs the T-cells loose from cancer's jail, Tumors stamped MSI-high or mismatch-repair undone Light up brightest for these drugs — that's where checkpoints have won. [Bridge] But unleash the immune system and it forgets to stand down, Colitis can mimic a belly crisis, mottling a surgeon's frown, Hepatitis creeps in quiet, hypophysitis steals your hormones whole, Don't reach first for a scalpel — steroids are the gentler goal, The tumor once performed a sly immunologic legerdemain, A conjurer's trick that hid it deep behind the T-cell's chain, Now the checkpoint drugs flip on the lights and name the sleight, Suddenly the hidden guest is standing in plain sight. [Verse 4] After high-risk GIST is cut, the story's not yet done, Three years of adjuvant imatinib keeps the battle won, Neoadjuvant immune drugs, given well before the knife, Shrink melanoma, shrink lung cancer, buying margins extra life, Surgery and medicine now move in closer step, Know the drug before you operate — and watch for what it's left. [Chorus] HER-two, trastuzumab, that's the breast and gastric aim, KIT and PDGFRA, imatinib's the name, Osimertinib quiets EGFR's restless flame, BRAF plus MEK, PD-one, CTLA-four — precision, not a guessing game. [Outro] Trastuzumab, imatinib, osimertinib, BRAF and MEK in tune, Pembro, nivo, ipilimumab, unmasking cancer's legerdemain too soon, Before you ever make an incision, know the targets, know the name — That's the surgeon's homework, that's precision's claim.
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