[Verse 1] Grandma's eyes skip a generation — recessive hides down low, Pedigree's the family map, autosomal or X, we trace the flow, Penetrance ain't a promise, carry the gene and still dodge the show, LOD score hits a three, that's a thousand-to-one — linkage locked, now we know. [Chorus] C'est dans les gènes, chérie, l'héritage qui parle, Statistique, mon amour, on cherche la trace, on cherche la marque, P less than five times ten to the negative eight — that's the genome-wide gate, Décode le code, mon cœur, décode le destin, ne débat pas. [Verse 2] Cases and controls, a million markers on parade, Call rate ninety-nine, Hardy-Weinberg keeps the drift delayed, Check the sex chromosomes, check who's kin, PCA clears the haze, REGENIE, SAIGE, BOLT-LMM — mixed models tame the maze. Stratification's a liar wearing ancestry's disguise, Ten components deep, we strip the bluff before it wins the prize. [Verse 3] Bonferroni's stingy, divide alpha 'til it's thin, Five times ten negative eight — the genome-wide gate lets few peaks in, FDR's the gentler judge, Benjamini keeps the false discovery slim, TOPMed's the deep well, Minimac and IMPUTE5 fill in every limb. Twins split at birth still echo the same disease refrain, GCTA-GREML, LDSC pull heritability straight out the summary chain. [Chorus] C'est dans les gènes, chérie, l'héritage qui parle, Statistique, mon amour, on cherche la trace, on cherche la marque, P less than five times ten to the negative eight — that's the genome-wide gate, Décode le code, mon cœur, décode le destin, ne débat pas. [Verse 4] SuSiE narrows the block down to a credible set, tight and small, FINEMAP bets on the causal one when ten variants stand tall, Coloc checks if the GWAS peak and the eQTL share one flame, TWAS wires expression straight to trait — same signal, different name. One rare variant alone just whispers, statistically it's weak, So SKAT and SKAT-O bundle the whispers 'til the burden starts to speak. [Bridge] Polygenic score — sum the weighted risk, but ancestry can betray it, Cross the continent, portability drops, recalibrate to save it, Mendelian randomization: instrument, exposure, outcome in a line, Pleiotropy sneaks in sideways — check your assumptions before you sign. [Chorus] C'est dans les gènes, chérie, l'héritage qui parle, Statistique, mon amour, on cherche la trace, on cherche la marque, P less than five times ten to the negative eight — that's the genome-wide gate, Décode le code, mon cœur, décode le destin, ne débat pas. [Outro] Manhattan skyline made of peaks, QQ plot keeps us honest, lambda close to one — Ma chérie, la trace est là, l'histoire du génome est écrite, mais jamais finie.
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