[Verse 1] Memory's not a single switch, it's layers in a stack Milliseconds up to lifetimes, each connection's got your back Short-term plasticity dancing at the synapse gate Calcium residue facilitating, vesicles that can't escape Facilitation builds the signal when the bursts come through High-pass filter catching onsets, makes the next release break through Depression drains the vesicle pool, adapts to constant flow Low-pass filtering for novelty, lets the background undertow [Chorus] Fire together, wire together, but the order's what we learn Pre before post gets stronger, flip it and the tables turn Twenty milliseconds window, causality's the key STDP detection, A preceded B [Verse 2] Hebbian learning had the concept but it couldn't find the brake Weights would spiral to infinity, unstable for learning's sake Correlation missed the timing, couldn't read the causal thread Till spike-timing came to rescue what the pioneers had said Delta T tells all the story in exponential decay A-plus strengthens forward connections, A-minus takes away When the pre-spike leads the party and the post-spike follows through Potentiation writes the memory of what the input knew [Chorus] Fire together, wire together, but the order's what we learn Pre before post gets stronger, flip it and the tables turn Twenty milliseconds window, causality's the key STDP detection, A preceded B [Bridge] Backpropagating action potential carries news from soma's fire Glutamate already binding in the spine's electric choir High calcium means potentiation, modest levels bring depression Order of operations writing each synaptic session [Verse 3] Not just co-activity patterns, but prediction in the link If A can tell you B is coming, strengthen that synaptic ink Swap the order of arrival, same two spikes but different fate LTD erases connections that arrived a moment late Dynamic filters shape the message, statistics in the stream Seconds-long reset cycles serving computation's dream From milliseconds up to lifetimes, every timescale has its place Memory's distributed symphony written in synaptic space [Verse 4] Competition shapes the landscape, winners take and losers fade Heterosynaptic depression keeps the total balance made Local clusters start to strengthen, distant inputs lose their hold Selectivity emerges from the stories spikes have told [Chorus] Fire together, wire together, but the order's what we learn Pre before post gets stronger, flip it and the tables turn Twenty milliseconds window, causality's the key STDP detection, A preceded B [Outro] Three-factor rules will gate the learning, relevance decides the weight But timing is the fundamental key that seals each synapse's fate
← Cells That Play Together Stay Together | Sliding Thresholds in the Neural Maze →