[Verse 1] Three billion base pairs scattered like dust DNA fragments in pieces we trust No picture on the box, no guide to see How do we solve this genetic mystery? [Chorus] Overlap, layout, consensus the way Smith-Waterman finds where the sequences play Assembly algorithms piece by piece Till the human genome finds its release Fragment by fragment, we build the code Walking the paths where the overlaps flowed [Verse 2] Sequence assembly like a puzzle so vast Reading the fragments from first to last Finding the overlaps, where do they meet? Making connections to make it complete [Chorus] Overlap, layout, consensus the way Smith-Waterman finds where the sequences play Assembly algorithms piece by piece Till the human genome finds its release Fragment by fragment, we build the code Walking the paths where the overlaps flowed [Bridge] Graph algorithms show us the routes Possible assemblies, following clues Paths through the network of overlapping parts Solving the riddle that science imparts [Verse 3] Twenty thousand genes, not what we thought Less than expected, but wisdom they brought Ninety-eight point eight with chimps we share Evolution's story written with care [Chorus] Overlap, layout, consensus the way Smith-Waterman finds where the sequences play Assembly algorithms piece by piece Till the human genome finds its release Fragment by fragment, we build the code Walking the paths where the overlaps flowed [Outro] Disease and evolution, mysteries solved The human story finally evolved From fragments to wholeness, the code complete Algorithm victory, no small feat
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