A3 — Human Anterolateral vs Posteromedial EC (alEC / pmEC)

melodic piano, duet male female · 4:03

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Lyrics

[Verse 1]
Rodent map got twisted when it landed in your skull
Ninety-degree turn, cortex doing a pull
Lateral slides forward, medial slides back
Anterolateral, posteromedial track
Same two players, brand new seats in the house
LEC's cousin now sits anterolateral, no doubt
MEC's cousin drifted posteromedial way
Rotation's the reason the homologs relay

[Chorus]
Anterolateral — object, texture, thing
Posteromedial — scene, compass, ring
Al-EC hugs the perirhinal crew
Pm-EC calls the parahippocampal true
Front-side objects, back-side space
Spin the rat brain, find the human place

[Verse 2]
Seven tesla scanner, Maass laid the wire
Two-thousand-fifteen, connectivity choir
Al-EC sings with anterior temporal band
Object network humming, texture in your hand
Pm-EC harmonizes with retrosplenial tone
Posterior medial system, scene and space alone
Navarro Schröder echoed the same divide
Two entorhinal rivers flowing side by side

[Verse 3]
Give a subject objects, watch al-EC ignite
Temporal order judgments spark that anterolateral light
Give a subject hallways, virtual streets to roam
Pm-EC lights the compass, guiding you back home
Function follows wiring, wiring follows the fold
This ain't rodent trivia, this is the human mold
Olsen's protocol drew the border with care
Segment on the scan, know exactly what's there

[Chorus]
Anterolateral — object, texture, thing
Posteromedial — scene, compass, ring
Al-EC hugs the perirhinal crew
Pm-EC calls the parahippocampal true
Front-side objects, back-side space
Spin the rat brain, find the human place

[Bridge]
Transentorhinal — that's the alEC zone
Where tau protein plants its very first throne
Braak stage whispers before the memory's gone
Tau-PET tracing where the damage drawn
Subregion volumetry, watching it shrink
Alzheimer's opening act, follow the link

[Verse 4]
Design a task: flash objects, silent and still
Ask which came first — that's the al-EC drill
Now drop them in a maze, no words, just walk
Retrieve the route from memory — pm-EC talk
One rotation, two circuits, one disease's start
Map the human entorhinal, know it by heart

[Verse 5]
Zoom past the surface, into layer two and three
Grid cells whisper metrics that the pm-EC decrees
Fan cells in al-EC tuned to feature and form
Two coding languages, one shared cortical norm
Comparative anatomy solved the naming fight
Homology's the compass that set the labels right
From Insausti's slices to Reagh's fMRI scan
The rotated rodent model built the modern human plan
Aging studies show the al-EC falter first
Object memory fading while the compass feels the worst
Track the subregions, chart the slow decline
Precision medicine starts by drawing the right line

[Chorus]
Anterolateral — object, texture, thing
Posteromedial — scene, compass, ring
Al-EC hugs the perirhinal crew
Pm-EC calls the parahippocampal true
Front-side objects, back-side space
Spin the rat brain, find the human place

← A2 — Lateral Entorhinal Cortex (LEC) | A4 — The Transentorhinal Region and Perirhinal Border →