[Verse 1] NMDA receptor, glutamate gate Calcium flooding through when you block it, that's fate Ketamine steps up, non-competitive bind Dissociative king, works the open-channel kind Phencyclidine cousin, arylcyclohexamine crew Subanesthetic dosing — low and slow is true Point one to point five per kilo IV Opioid-sparing surgery, that's the clinical key Wind-up phenomenon, central sensitization Ketamine interrupts that synaptic conversation [Chorus] Антагонисты NMDA — блокируй канал Ketamine, dextromethorphan — учи материал Magnesium, memantine в игру входят тут NMDA antagonists — pain в обход идут [Verse 2] Perioperative pain, refractory cases too Esketamine — S-enantiomer, more potent view Intranasal Spravato for treatment-resistant depression Psychotomimetic side effects need your full attention Hallucinations, dissociation, emergence reaction Benzodiazepines nearby for hostile interaction Hepatotoxicity — liver enzymes climbing high Chronic dosing, check those LFTs, don't let it slide by Ketamine cystitis — bladder wall contracting, scarred Interstitial fibrosis when the recreational use hits hard [Chorus] Антагонисты NMDA — блокируй канал Ketamine, dextromethorphan — учи материал Magnesium, memantine в игру входят тут NMDA antagonists — pain в обход идут [Bridge] Dextromethorphan — cough syrup with a secret role Low-affinity NMDA block, adjuvant on parole Quinidine combo boosts the bioavailability code Nuedexta formulation walking that clinical road Memantine — Alzheimer's drug, NMDA block mild Chronic pain data stays inconclusive, evidence exiled Magnesium — physiologic channel blocker, natural gatekeeper Perioperative infusions, but the evidence ain't deeper Abuse potential, ketamine — Schedule Three controlled Dissociative high, the Special K story been told [Verse 3] So stratify your patients, monitor the mind Subanesthetic bolus, infusion pump designed Intraoperative ketamine cuts your morphine need Refractory pain syndromes — neuropathic, cancer, freed Psychomimetic prophylaxis, keep the midazolam near Low-dose regimens minimize the psychedelic frontier Esketamine nasal spray, supervised clinic dose Treatment-resistant cases where opioids got too close Hepatic function quarterly if you're dosing chronic-long NMDA antagonism — block that calcium-ion song [Chorus] Антагонисты NMDA — блокируй канал Ketamine, dextromethorphan — учи материал Magnesium, memantine в игру входят тут NMDA antagonists — pain в обход идут [Outro] Eight NMDA antagonists, ketamine leads the pack Esketamine, dex, memantine, magnesium got your back Block the open channel, calcium can't cascade Wind-up sensitization — clinical pain gets paid Блокируй, учи, запомни — NMDA
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