[Verse 1] Deoxyribose spine, a backbone link between, Adenine, Cytosine, Guanine, Thymine — the coded scene, Purines are the double rings, A and G stand wide, Pyrimidines, C and T, single rings collide, Sugar-acid bonds stitch the ladder tight, Five prime to three prime, we're reading left to right, But the partner strand runs backwards, antiparallel design, Two roads facing traffic, tangled up in twine. [Chorus] Zucker, Rückgrat, und die Basen vier, A findet T, zwei Brücken halten hier, G und C, drei Brücken, fester Bund, Doppelhelix dreht sich — komm, wir tanzen im Grund. Stacking is the muscle, bonds just steady the frame, Antiparallel lovers who never share a name. [Verse 2] Watson-Crick pairing, geometry so precise, Two bonds for A-T, that's the cheaper price, Three bonds lock G-C, harder grip to break, But it's the stacking bases doing heavy lifting for the stake, B-DNA's the classic, wide and gently curled, A-form tightens up when the water's pearled, Z-DNA zigzags left when purines alternate — Structure isn't fixed, it's a conversation with its state. [Chorus] Zucker, Rückgrat, und die Basen vier, A findet T, zwei Brücken halten hier, G und C, drei Brücken, fester Bund, Doppelhelix dreht sich — komm, wir tanzen im Grund. [Verse 3] Four G-tracts fold into a quadruplex knot, Regex hunts them, G three plus in every slot, Hairpins fold on cruciforms, triplex adds a third, R-loops let RNA squat where the duplex once occurred, i-motifs love the acid, C-runs curling tight, Melting temp depends on how the letters bite — Wallace rule's a shortcut, nearest-neighbor's the truth, Supercoils get loosened by topoisomerase, forsooth. [Verse 4] 5-methyl-C, 6mA, marks written in the code, 8-oxo-G's the damage when oxygen corrodes, Deamination turns a C into a ghostly U, UV welds two thymines — that dimer's overdue, Ancient bones leak C to T where the strand end frays, Single-stranded overhangs betray their broken days, Sense or antisense, template, coding, plus or minus track, Complement it, flip it, N and R and Y ride shotgun on the map. [Bridge] Kein Zufall — jede Base hat ihren Platz, Reverse complement, ich lese dich im Satz, Skew zeigt mir den Ursprung, wo die Kurven sich drehen, Ori versteckt im G minus C — ich kann's schon sehen. [Chorus] Zucker, Rückgrat, und die Basen vier, A findet T, zwei Brücken halten hier, G und C, drei Brücken, fester Bund, Doppelhelix dreht sich — komm, wir tanzen im Grund. Stacking is the muscle, bonds just steady the frame, Antiparallel lovers who never share a name. [Outro] Fünf zu drei, drei zu fünf, gegenläufig, treu, Read the ladder closely — the code was always new.
← Module 0 — Computational Environment Setup (Week 0) | Module 2 — Genome Biology & Organization (Weeks 3–4) →