[Verse 1] WHO CNS5 rewrote the atlas of the brain, Histology alone can't carry all the weight of what we name, Integrated diagnosis — molecular plus the slide, IDH mutation status tells you which side you're on inside, Astrocytoma mutant, grades two up through four, Lose your CDKN2A and B and suddenly you're more, Homozygous deletion — grade four without GBM's face, Oligodendroglioma needs the one-p nineteen-q erased [Chorus] IDH, TERT, EGFR amplified, Plus seven minus ten — wildtype glioblast certified, NOS when the markers never came back clear, NEC when the profile contradicts the frontier, Read the molecule, not just the cell, Integration is the doctrine — learn to read it well [Verse 2] Pediatric gliomas carry histone scars instead, H3 K27-altered diffuse midline — brainstem, widespread dread, G34 mutant hemispheric, ATRX in its wake, Low-grade group rides BRAF and FGFR through every twist and break, Pilocytic astrocytoma wears a KIAA1549 fusion coat, PXA carries BRAF V600E — targeted agents take note, Subependymal giant cells bloom in tuberous sclerosis ground, Ependymomas sorted by location where they're found — Supratentorial ZFTA or YAP1 drives the type, Posterior fossa A methylated, B a different stripe [Chorus] IDH, TERT, EGFR amplified, Plus seven minus ten — wildtype glioblast certified, NOS when the markers never came back clear, NEC when the profile contradicts the frontier, Read the molecule, not just the cell, Integration is the doctrine — learn to read it well [Bridge] Medulloblastoma stratifies by WNT and SHH, Group three carries amplified MYC — the one that chills your breath, Group four, the most abundant, intermediate terrain, Risk stratification shapes how aggressively we drain, Lymphoma whispers — biopsy only, never take the mass, Hold the steroids till the needle passes through the glass, Methotrexate is the backbone, systemic then CNS, Melanoma bleeds into itself — a hemorrhagic mess, Renal, choriocarcinoma, thyroid in that list, Leptomeningeal seeding — the diffusion you have missed [Verse 3] Five-ALA fluoresces porphyrin through the malignant seam, Stummer's trials proved the pink light isn't merely surgeon's dream, Supratotal FLAIRectomy harvests the infiltrated rim, Intraoperative MRI recalibrates the interim, Awake craniotomy maps the cortex while it speaks, Staged resection honours plasticity across the weeks, The resection cavity holds all the evidence we need — Molecular margins, functional margins, both must heed [Chorus] IDH, TERT, EGFR amplified, Plus seven minus ten — wildtype glioblast certified, NOS when the markers never came back clear, NEC when the profile contradicts the frontier, Read the molecule, not just the cell, Integration is the doctrine — learn to read it well
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